The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis.
نویسندگان
چکیده
We examined the relationship between serum and bronchoalveolar lavage (BAL) galactomannan index (GMI) values and mortality in allogeneic hematopoietic cell transplant recipients with invasive pulmonary aspergillosis. Using a clinical sign and symptom-initiated approach, we found that the serum but not the BAL GMI level correlated with 42- and 180-day patient mortality.
منابع مشابه
Screening with serum galactomannan might be associated with better outcome than symptom-triggered galactomannan testing in allogeneic HSCT recipients with invasive aspergillosis.
TO THE EDITOR—We read with interest the article by Fisher and colleagues about use of the galactomannan index (GMI) in hematopoietic stem cell transplant (HSCT) recipients with invasive aspergillosis (IA) [1]. The authors reported that the serum GM level at the time of IA diagnosis was significantly associated with the risk of overall and respiratory mortality. In their cohort, GM testing was p...
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Invasive aspergillosis (IA) is a severe complication among hematopoietic stem cell transplant recipients or patients with hematological malignancies and neutropenia following anti-cancer therapy. Moreover, IA is increasingly observed in other populations, such as solid-organ transplant recipients, patients with solid tumors or auto-immune diseases, and among intensive care unit patients. Freque...
متن کاملThe limited role of serum galactomannan assay in screening for invasive pulmonary aspergillosis in allogeneic stem cell transplantation recipients on micafungin prophylaxis: a retrospective study
Background We evaluated the outcomes of serum galactomannan (GM) assay for the screening of invasive pulmonary aspergillosis (IPA) in allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients while on primary antifungal prophylaxis (PAP). Methods This study included patients with hematologic disorders who underwent alloHSCT from January 2013 to November 2015. Patients received ...
متن کاملارزیابی سطح سرمی آنتی ژن گالاکتومانان به منظور تشخیص آسپرژیلوزیس مهاجم در بیماران مبتلا به بدخیمی های خونی و گیرندگان پیوند مغز استخوان
Background and purpose: Invasive aspergillosis, is a serious fatal disease caused by fungal species of Aspergillus in patients with neutropenia, bone marrow transplant recipients, patients with blood disorders, chronic granulomatous disease, recipients of long-term steroids or antibiotics. Galactomannan antigen (GM) is a polysaccharide of Aspergillus present in the cell wall of Aspergillus spp....
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Invasive aspergillosis is one the major causes of death in hematopoietic and solidtransplantrecipients. One of the most critical problems in medical mycology is theinability to consistently make a convincing and early diagnosis of invasive fungalinfection. Conventional diagnosis methods such as culture-based approaches are limitedby the insufficient accessibility sensitivity and the non-culture...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 57 7 شماره
صفحات -
تاریخ انتشار 2013